N-methyl-D-aspartate-receptor antibodies, S100B protein, and neuron-specific enolase before and after cardiac surgery: association with ischemic brain injury and erythropoetin prophylaxis

摘要

Objective: To evaluate biomarkers of acute ischemic brain injury after surgical revascularization of the heart with the use of the heart-lung machine(ie, cardiopulmonary bypass [CPB]). Methods Twenty consecutive patients were divided into 2 groups: the first 10 patients received a potential neuro protective human recombinant erythropoietin and the remaining 10 comprised the control group. Neurological complications were monitored by measuring serum concentrations of N-methyl-D-aspartate (NMDA)-receptor antibodies (NR2Ab), S100B protein, and neuron-specific enolase (NSE) before and during the first 5 days after surgery, comparing the neurological outcome with the results of MRI examinations. Results The results from the erythropoietin-treated group and the control group were similar, with a significant difference shown for the postoperative NSE. Comparison of serum concentrations of the biomarkers of 16 patients without brain ischemia and 4 patients with acute ischemia displayed significant differences for only postoperative NR2Ab, regardless if the patient received erythropoietin therapy. Conclusions The analysis of NR2Ab serum concentrations might be useful for monitoring neuroprotective stroke treatment